Product Overview
Venadaparib | T9430 | TargetMol Chemicals
CAS: 1681017-83-3
Smiles: O=C(c(cc(CC(c1c2cccc1)=NNC2=O)cc1)c1F)N1CC(CNC2CC2)C1
Formula: C23H23FN4O2
Pathway: Chromatin/Epigenetic|||DNA Damage/DNA Repair
Target: PARP
Receptor: N/A
Bioactivity: Venadaparib (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the repair of DNA single-strand breaks (SSBs) and can be used in solid tumor research.
Molecular Weight: 406, 45