Product Overview
VU-29 | T23515 | TargetMol Chemicals
CAS: 890764-36-0
Smiles: [O-][N+](=O)c1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1
Formula: C22H16N4O3
Pathway: Neuroscience
Target: GluR
Receptor: N/A
Bioactivity: VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM).
Molecular Weight: 384, 395
