Product Overview
VU0463271 | T17243 | TargetMol Chemicals
CAS: 1391737-01-1
Smiles: Cc1csc(n1)N(C1CC1)C(=O)CSc1ccc(nn1)-c1ccccc1
Formula: C19H18N4OS2
Pathway: Membrane transporter/Ion channel
Target: Potassium Channel
Receptor: N/A
Bioactivity: VU0463271 is a potent and selective antagonist of the neuronal-specific potassium-chloride cotransporter 2 (KCC2), with an IC50 of 61 nM and >100-fold selectivity versus the closely related Na-K-2Cl cotransporter 1 (NKCC1) and no activity in a larger panel of GPCRs, ion channels, and transporters.
Molecular Weight: 382, 5