Product Overview
W-54011 | T17250 | TargetMol Chemicals
CAS: 405098-33-1
Smiles: Cl.COc1ccc2CCCC(C(=O)N(Cc3ccc(cc3)N(C)C)c3ccc(cc3)C(C)C)c2c1
Formula: C30H37ClN2O2
Pathway: Immunology/Inflammation
Target: ROS|||Complement System
Receptor: N/A
Bioactivity: W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki = 2.2 nM). W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophils (IC50s = 3.1 nM, 2.7 nM, and 1.6 nM, respectively).
Molecular Weight: 493, 09
