Product Overview
WHI-P97 HCl 211555-05-4(free base) | T4657L | TargetMol Chemicals
CAS: T4657L
Smiles: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C(=C3)Br)O)Br)OC.Cl
Formula: C16H14Br2ClN3O3
Pathway: Angiogenesis|||Chromatin/Epigenetic|||JAK/STAT signaling|||Stem Cells
Target: JAK
Receptor: N/A
Bioactivity: WHI-P97 HCl is a potent and selective JAK-3 inhibitor. WHI-P97 had an estimated Ki value of 0.09 microM from modeling studies and a measured IC50 value of 2.5 microM in EGFR kinase inhibition assays. WHI-P97 effectively inhibited the in vitro invasiveness of EGFR-positive human cancer cells in a concentration-dependent manner.
Molecular Weight: 491, 56
