Product Overview
WHI-P97 | T4657 | TargetMol Chemicals
CAS: 211555-05-4
Smiles: COc1cc2ncnc(Nc3cc(Br)c(O)c(Br)c3)c2cc1OC
Formula: C16H13Br2N3O3
Pathway: Angiogenesis|||Chromatin/Epigenetic|||JAK/STAT signaling|||Stem Cells
Target: JAK
Receptor: N/A
Bioactivity: WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcepsilonRI crosslinking by >90% at low micromolar concentrations. WHI-P97 did not directly inhibit the enzymatic activity of 5-LO, but prevented its translocation to the nuclear membrane without affecting the requisite calcium signal.
Molecular Weight: 455, 106
