Product Overview
WP1066 | T2156 | TargetMol Chemicals
CAS: 857064-38-1
Smiles: C[C@H](NC(=O)C(=C\c1cccc(Br)n1)\C#N)c1ccccc1
Formula: C17H14BrN3O
Pathway: Angiogenesis|||Apoptosis|||Chromatin/Epigenetic|||JAK/STAT signaling|||Stem Cells
Target: Apoptosis|||JAK|||STAT
Receptor: N/A
Bioactivity: WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 has been used in trials studying the treatment of Melanoma, Brain Cancer, Solid Tumors, and Central Nervous System Neoplasms.
Molecular Weight: 356, 223
