Product Overview
XL413 hydrochloride | T6735 | TargetMol Chemicals
CAS: 1169562-71-3
Smiles: Cl.Clc1ccc2oc3c(nc([nH]c3=O)[C@@H]3CCCN3)c2c1
Formula: C14H13Cl2N3O2
Pathway: Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||GPCR/G Protein|||JAK/STAT signaling|||Metabolism|||Stem Cells
Target: cholecystokinin|||Casein Kinase|||Pim|||CDK
Receptor: N/A
Bioactivity: XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor BMS-863233 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. CDC7, a serine-threonine kinase overexpressed in a variety of tumor cell types, plays an essential role in the initiation of DNA replication by activating origins of replication.
Molecular Weight: 326, 18
