Product Overview
YUM70 | T8901 | TargetMol Chemicals
CAS: 423145-35-1
Smiles: CCCC(=O)NC(c1ccc2OCOc2c1)c1cc(Cl)c2cccnc2c1O
Formula: C21H19ClN2O4
Pathway: Apoptosis|||Cytoskeletal Signaling|||Endocrinology/Hormones|||GPCR/G Protein|||Metabolism
Target: Apoptosis|||GPR|||HSP
Receptor: N/A
Bioactivity: YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.
Molecular Weight: 398, 84