Product Overview
(Z)-Semaxinib | T2496 | TargetMol Chemicals
CAS: 194413-58-6
Smiles: Cc1cc(C)c(\C=C2/C(=O)Nc3ccccc23)[nH]1
Formula: C15H14N2O
Pathway: Angiogenesis|||Tyrosine Kinase/Adaptors
Target: VEGFR
Receptor: N/A
Bioactivity: Semaxanib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR over PDGFRβ, no inhibition for FGFR, InsR, and EGFR. Semaxanib is a quinolone derivative with potential antineoplastic activity.
Molecular Weight: 238, 28
