Product Overview
ZINC72115182 | T19802 | TargetMol Chemicals
CAS: 918504-27-5
Smiles: CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Br)cc23)c1F
Formula: C17H14BrF2N3O3S
Pathway: MAPK
Target: Raf
Receptor: N/A
Bioactivity: N-(3-(5-Bromo-1H-pyrrolo[2, 3-b]pyridine-3-carbonyl)-2, 4-difluorophenyl)propane-1-sulfonamide is a novel selective inhibitor. The DFG-in conformation of the B-Raf kinase V600E mutant is superior to the DFG-out conformation in colorectal cancer.
Molecular Weight: 458, 28