Product Overview
ZK 756326 | T3360 | TargetMol Chemicals
CAS: 874911-96-3
Smiles: C1CN(CCN1CCOCCO)CC2=CC(=CC=C2)OC3=CC=CC=C3.Cl.Cl
Formula: C21H28N2O3·2HCl
Pathway: Immunology/Inflammation|||Microbiology/Virology
Target: CCR
Receptor: N/A
Bioactivity: ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8 μM, in human; 2.6 μM, in mouse). Displays no activity at CCR4/5 and CXCR3/4 and shows higher 28-fold selectivity over 26 other GPCRs (less selective at α2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.
Molecular Weight: 429, 38
