ZM-447439 | T6077

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€170.00 - €616.00
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TMC-T6077
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Product Overview

ZM-447439 | T6077 | TargetMol Chemicals

CAS: 331771-20-1

Smiles: COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCCCN1CCOCC1

Formula: C29H31N5O4

Pathway: Angiogenesis|||Apoptosis|||Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||MAPK|||Tyrosine Kinase/Adaptors

Target: Apoptosis|||MEK|||Src|||Aurora Kinase

Receptor: N/A

Bioactivity: ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.

Molecular Weight: 513, 598

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