Product Overview
Zotepine | T19680 | TargetMol Chemicals
CAS: 26615-21-4
Smiles: CN(C)CCOC1=Cc2ccccc2Sc2ccc(Cl)cc12
Formula: C18H18ClNOS
Pathway: GPCR/G Protein|||Immunology/Inflammation|||Neuroscience
Target: Dopamine Receptor|||5-HT Receptor|||Adrenergic Receptor|||Histamine Receptor
Receptor: N/A
Bioactivity: Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. Zotepine is a second-generation antipsychotic with a primary use as a treatment for schizophrenia, although clinical trials have been conducted into its efficacy as an antimanic agent in patients with acute bipolar mania.
Molecular Weight: 331, 86
