2-Methoxystypandrone | TN2775

2-Methoxystypandrone | TN2775 | TargetMol Chemicals

CAS: 85122-21-0

Smiles: COC1=CC(=O)c2c(O)c(C(C)=O)c(C)cc2C1=O

Formula: C14H12O5

Pathway: Angiogenesis|||Apoptosis|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||Immunology/Inflammation|||JAK/STAT signaling|||Neuroscience|||NF-Κb|||PI3K/Akt/mTOR signaling|||Proteases/Proteasome|||Stem Cells

Target: MMP|||BCL|||IκB/IKK|||GSK-3|||TNF|||NOS|||NF-κB|||Wnt/beta-catenin|||COX|||JAK|||STAT

Receptor: N/A

Bioactivity: 2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins.2-Methoxystypandrone has anti-osteoclastogenic effect, could reflect the block of RANKL-induced association of TRAF6-TAK1 complexes with consequent decrease of IkappaB-mediated NF-kappaB and mitogen-activated protein kinases-mediated c-Fos activation pathways and suppression of NFATc1 and other gene expression, essential for bone resorption.

Molecular Weight: 260, 2