Product Overview
4beta-Hydroxywithanolide E | TN3070 | TargetMol Chemicals
CAS: 54334-04-2
Smiles: CC1=C(C)C(=O)OC(C1)[C@](C)(O)[C@]1(O)CC[C@@]2(O)[C@@H]3C[C@H]4O[C@]44[C@@H](O)C=CC(=O)[C@]4(C)[C@H]3CC[C@]12C
Formula: C28H38O8
Pathway: Chromatin/Epigenetic|||Cytoskeletal Signaling|||DNA Damage/DNA Repair|||Immunology/Inflammation|||Metabolism|||Neuroscience|||NF-Κb
Target: PARP|||HSP|||NF-κB|||COX
Receptor: N/A
Bioactivity: 4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it affects alternative splicing by modulating splicing factors and histone modifications.4bHWE is a useful natural anti-inflammatory compound to attenuate progression of diabetes and obesity, it decreases inflammatory responses by inhibiting the NF-κB signaling in diabetic mouse adipose tissue, it also can improve impaired glucose tolerance.
Molecular Weight: 502, 6
