5-Hydroxy-1-methylhydantoin | T28222

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€308.00 - €2,006.00
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Product Overview

5-Hydroxy-1-methylhydantoin | T28222 | TargetMol Chemicals

CAS: 84210-26-4

Smiles: O=C1NC(CN1C)=O

Formula: C4H6N2O2

Pathway: GPCR/G Protein

Target: Bradykinin Receptor

Receptor: N/A

Bioactivity: NZ-419 is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, NZ-419, a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. NZ-419 a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. NZ-419 inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that NZ-419 may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.

Molecular Weight: 114, 1


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