Product Overview
5-Hydroxy-1-methylhydantoin | T28222 | TargetMol Chemicals
CAS: 84210-26-4
Smiles: O=C1NC(CN1C)=O
Formula: C4H6N2O2
Pathway: GPCR/G Protein
Target: Bradykinin Receptor
Receptor: N/A
Bioactivity: NZ-419 is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, NZ-419, a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. NZ-419 a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. NZ-419 inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that NZ-419 may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.
Molecular Weight: 114, 1
