Product Overview
Acetylcorynoline | T5S2357 | TargetMol Chemicals
CAS: 18797-80-3
Smiles: CN1Cc2c3OCOc3ccc2[C@@]2(C)[C@H](Cc3cc4OCOc4cc3[C@@H]12)OC(C)=O
Formula: C23H23NO6
Pathway: Microbiology/Virology
Target: Antifungal
Receptor: N/A
Bioactivity: 1. Acetylcorynoline has antifungal、anti-inflammatory activity. 2. Acetylcorynoline may be one of the potent immunosuppressive agents through the blockage of dendritic cells maturation and function. 3. Acetylcorynoline is potential as a possible antiparkinsonian drug. (1) Significantly decreases dopaminergic neuron degeneration induced by 6-hydroxydopamine in BZ555 strain; (2) Prevents α-synuclein aggregation; (3) Restores food-sensing behavior, and dopamine levels; (4) Prolongs life-span in 6-hydroxydopamine-treated N2 strain. 4. Acetylcorynoline may exert its effects by decreasing egl-1 expression to suppress apoptosis pathways and by increasing rpn5 expression to enhance the activity of proteasomes.
Molecular Weight: 409, 438
