Product Overview
AMG-1694 | T14212 | TargetMol Chemicals
CAS: 1361217-07-3
Smiles: C[C@H]1COCCN1C[C@H]1CN(CCN1c1ccc(cc1)[C@@](C)(O)C(F)(F)F)S(=O)(=O)c1cccs1
Formula: C23H30F3N3O4S2
Pathway: Metabolism
Target: Glucokinase
Receptor: N/A
Bioactivity: AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1]. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation.
Molecular Weight: 533, 63
