Product Overview
AMG-47a | T7123 | TargetMol Chemicals
CAS: 882663-88-9
Smiles: Cc1ccc(cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F
Formula: C29H28F3N5O2
Pathway: Angiogenesis|||Chromatin/Epigenetic|||JAK/STAT signaling|||MAPK|||Stem Cells|||Tyrosine Kinase/Adaptors
Target: VEGFR|||p38 MAPK|||JAK|||Src
Receptor: N/A
Bioactivity: AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.
Molecular Weight: 535, 571
