Product Overview
AMG 511 | T14214 | TargetMol Chemicals
CAS: 1253573-53-3
Smiles: COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)[C@@H](C)N2CCN(CC2)S(C)(=O)=O)cc1F
Formula: C22H28FN9O3S
Pathway: PI3K/Akt/mTOR signaling
Target: PI3K
Receptor: N/A
Bioactivity: AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3KĪ±, Ī², Ī“ and Ī³, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease.
Molecular Weight: 517, 58
