Product Overview
AMG 900 | T6380 | TargetMol Chemicals
CAS: 945595-80-2
Smiles: Cc1csc(c1)-c1nnc(Nc2ccc(Oc3ncccc3-c3ccnc(N)n3)cc2)c2ccccc12
Formula: C28H21N7OS
Pathway: Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||MAPK|||Tyrosine Kinase/Adaptors
Target: p38 MAPK|||Tyrosine Kinases|||Aurora Kinase
Receptor: N/A
Bioactivity: AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.
Molecular Weight: 503, 58
