Product Overview
Antisauvagine-30 | TP2091 | TargetMol Chemicals
CAS: 220673-95-0
Smiles:
Formula: C161H274N48O46S
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist (Kd values are 1.4 and 153.6 nM for binding to mouse CRF2β and rat CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF2β cells (pA2 = 8.49). Prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice in vivo.
Molecular Weight: 3650, 29
