Arnicolide D | TN1405

Arnicolide D | TN1405 | TargetMol Chemicals

CAS: 34532-68-8

Smiles: C[C@H]1[C@@H]2[C@@H](C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@H]2OC(=O)C(C)=C)OC1=O

Formula: C19H24O5

Pathway: Apoptosis|||Cytoskeletal Signaling|||JAK/STAT signaling|||PI3K/Akt/mTOR signaling|||Proteases/Proteasome|||Stem Cells

Target: Akt|||Caspase|||PI3K|||STAT|||mTOR

Receptor: N/A

Bioactivity: Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D exerts strong cytotoxic activity on the human colon carcinoma HT-29 cell line.

Molecular Weight: 332, 396