Product Overview
ATP-polyamine-biotin | T17454 | TargetMol Chemicals
CAS: 1800401-93-7
Smiles: [H][C@]12CS[C@@H](CCCCC(=O)NCCCN(C)CCCCN(C)CCCNP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)[C@@]1([H])NC(=O)N2
Formula: C32H58N11O14P3S
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: ATP-polyamine-biotin is a cell-permeable, efficient kinase cosubstrate with conversions and kinetics similar to those of other known ATP analogues. APB shows a cytotoxicity EC50 value of 19 ± 1 mM. ATP-polyamine-biotin is shown to promote biotin labeling of kinase substrates in live cells and has future applications in phosphoprotein purification and analysis. APB is cell-permeable and nontoxic at low mM concentrations, with cell penetration and labeling dependent on the polyamine linker.
Molecular Weight: 945, 86
