Product Overview
AVN-101 | T26690 | TargetMol Chemicals
CAS: 1061354-48-0
Smiles: Cl.CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccc1
Formula: C21H25ClN2
Pathway: GPCR/G Protein|||Immunology/Inflammation|||Neuroscience
Target: 5-HT Receptor|||Adrenergic Receptor|||Histamine Receptor
Receptor: N/A
Bioactivity: AVN-101 is a very potent 5-HT7 receptor antagonist (Ki = 153 pM). AVN-101 also exhibits a rather high affinity toward histamine H1 (Ki = 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki = 0.41-3.6 nM) receptors. AVN-101 shows a good oral bioavailability and facilitated brain-blood barrier permeability, low toxicity, and reasonable efficacy in animal models of CNS diseases.
Molecular Weight: 340, 9
