Product Overview
Bafilomycin A1 | T6740 | TargetMol Chemicals
CAS: 88899-55-2
Smiles: CO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C=C(OC)\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C
Formula: C35H58O9
Pathway: Apoptosis|||Autophagy|||Membrane transporter/Ion channel|||Microbiology/Virology
Target: Apoptosis|||Proton pump|||Antibacterial|||Antibiotic|||Autophagy
Receptor: N/A
Bioactivity: Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. Bafilomycin A1 is a vacuolar H+-ATPase inhibitor (IC50: 0.44 nM). It is also found to inhibit autophagy while induces apoptosis.Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice.
Molecular Weight: 622, 84
