Product Overview
Bigelovin | TN6735 | TargetMol Chemicals
CAS: 3668-14-2
Smiles: C[C@H](C[C@@H]([C@H]([C@@H]([C@]12C)OC(C)=O)C3=C)OC3=O)[C@@H]2C=CC1=O
Formula: C17H20O5
Pathway: Apoptosis|||Autophagy|||Immunology/Inflammation|||Metabolism|||NF-Κb
Target: Apoptosis|||Reactive Oxygen Species|||Retinoid Receptor|||Autophagy|||RAR/RXRÂ
Receptor: N/A
Bioactivity: Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a potent cytotoxic sesquiterpene lactone from Inula sp.
Molecular Weight: 304, 34