Product Overview
Bim-BLK-A | T26817 | TargetMol Chemicals
CAS: T26817
Smiles: O=C1C=CC(C2=NC(S(=O)(C)=O)=NC(C(F)(F)F)=C2)=CN1CC3=CC=C(OC)C(OC)=C3
Formula: C20H18F3N3O5S
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Bim-BLK-A efficiently blocks Bim-induced apoptosis after Bax is activated on the mitochondria. The cellular target of Bim-BLK-A was identified to be the succinate dehydrogenase subunit B (SDHB) protein of complex II of the mitochondrial electron transfer chain (ETC). Bim-BLK-A protects the integrity of the ETC and allows treated cells to continue to proliferate after apoptosis induction.
Molecular Weight: 469, 44
