Product Overview
Bisantrene | T4047 | TargetMol Chemicals
CAS: 78186-34-2
Smiles: C1CN=C(N\N=C\c2c3ccccc3c(\C=N\NC3=NCCN3)c3ccccc23)N1
Formula: C22H22N8
Pathway: DNA Damage/DNA Repair
Target: Topoisomerase
Receptor: N/A
Bioactivity: Bisantrene is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity.
Molecular Weight: 398, 474
