Product Overview
BL-1249 | T14666 | TargetMol Chemicals
CAS: 18200-13-0
Smiles: C1CCc2c(C1)cccc2Nc1ccccc1-c1nnn[nH]1
Formula: C17H17N5
Pathway: Membrane transporter/Ion channel
Target: Potassium Channel
Receptor: N/A
Bioactivity: BL-1249 is a nonsteroidal anti-inflammatory drug (NSAID) and a potassium channel activator. BL-1249 exhibits more selective for the bladder (EC50 of 1.26 μM) than vascular tissue (EC50 of 21.0 μM). BL-1249 extracellular application activates all TREK subfamily members but has no effect on other K2P subfamilies. BL-1249 potently activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with EC50 values of 5.5 μM and 8.0 μM, respectively[1][2].
Molecular Weight: 291, 358
