Product Overview
BMS 599626 dihydrochloride (714971-09-2 free base) | T22610 | TargetMol Chemicals
CAS: T22610
Smiles: CC(C(/N=C(OC[C@]1([H])COCCN1)\O)=CN2NC=N/3)=C2C3=N\C4=CC=C5C(C=NN5CC6=CC(F)=CC=C6)=C4.Cl.Cl
Formula: C27H27FN8O3·2HCl
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: BMS 599626 dihydrochloride is a potent and selective EGFR and ErbB2 inhibitor. BMS-599626 inhibited HER4 (IC50: 190 nM). In Sal2, N87, and GEO tumor cells, BMS-599626 inhibited phosphorylation of HER1 and HER2 in a dose-dependent way and inhibited cell proliferation. In AU565 breast cancer cells, BMS-599626 (1μM) inhibited HER1/HER2 heterodimer formation. In tumor cells that forming HER1/HER2 heterodimers, BMS-599626 inhibited heterodimerization [1][2].
Molecular Weight: 603, 48
