Product Overview
CALP1 acetate | TP1910L1 | TargetMol Chemicals
CAS: TP1910L1
Smiles: CC[C@]([H])(C)[C@@]([H])(/C(O)=N/[C@@]([H])([C@@]([H])(C)O)/C(O)=N/[C@@]([H])(C(C)C)/C(O)=N/[C@@]([H])(CC(C)C)/C(O)=N/[C@@]([H])(C(C)C)/C(O)=N/[C@@]([H])(CCCCN)C(O)=O)/N=C([C@]([H])(C)/N=C([C@]([H])(C(C)C)N)\O)\O.CC(O)=O
Formula: C42H79N9O12
Pathway: Neuroscience
Target: CaMK
Receptor: N/A
Bioactivity: CALP1 acetate is a calmodulin (CaM) agonist (Kd of 88 µM) that binds to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) by inhibiting the open of calcium channel. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity.
Molecular Weight: 902, 13
