Product Overview
CALP1 | TP1910 | TargetMol Chemicals
CAS: 145224-99-3
Smiles:
Formula: C40H75N9O10
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 μM). Shown to protect pancreatic acinar cells from gossypol induced necrosis. Inhibits VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo.
Molecular Weight: 842, 09
