Product Overview
CAN508 | T8796 | TargetMol Chemicals
CAS: 140651-18-9
Smiles: Nc1n[nH]c(N)c1\N=N\c1ccc(O)cc1
Formula: C9H10N6O
Pathway: Cell Cycle/Checkpoint
Target: CDK
Receptor: N/A
Bioactivity: CAN508 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. It is also a competitive inhibitor of Cdk2-cyclin E with respect to ATP, with Ki and IC50 values of 13.3 and 20 μM, respectively.CAN508 exhibits a 38-fold selectivity for CDK9/cyclin T over other CDK/cyclin complexes. Antitumor activity.
Molecular Weight: 218, 22