Product Overview
CDDO-dhTFEA | T13604 | TargetMol Chemicals
CAS: 1191265-33-4
Smiles: [H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)[C@]2([H])C(=O)C[C@@]2([H])[C@@]1(C)CC[C@@]1([H])C(C)(C)C(=O)C(=C[C@]21C)C#N)C(=O)NCC(F)(F)F
Formula: C33H45F3N2O3
Pathway: Immunology/Inflammation|||NF-Κb|||Others
Target: Others|||NF-κB|||Nrf2
Receptor: N/A
Bioactivity: CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. It restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats.
Molecular Weight: 574, 729
