Product Overview
Ceralasertib formate | T26981 | TargetMol Chemicals
CAS: 1352280-98-8
Smiles: OC=O.C[C@@H]1COCCN1c1cc(nc(n1)-c1ccnc2[nH]ccc12)C1(CC1)[S@](C)(=N)=O
Formula: C21H26N6O4S
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Ceralasertib is an orally available inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase. Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis.
Molecular Weight: 458, 54
