Product Overview
CHIR-124 | T6350 | TargetMol Chemicals
CAS: 405168-58-3
Smiles: Clc1ccc2[nH]c(=O)c(-c3nc4ccccc4[nH]3)c(N[C@@H]3CN4CCC3CC4)c2c1
Formula: C23H22ClN5O
Pathway: Angiogenesis|||Apoptosis|||Cell Cycle/Checkpoint|||PI3K/Akt/mTOR signaling|||Stem Cells|||Tyrosine Kinase/Adaptors
Target: Apoptosis|||GSK-3|||FLT|||Chk|||PDGFR|||Src
Receptor: N/A
Bioactivity: CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.
Molecular Weight: 419, 91
