Product Overview
CHIR98014 HCl (252935-94-7 free base) | T3074L | TargetMol Chemicals
CAS: T3074L
Smiles: NC1=NC(NCCNC2=NC=C(N3C=CN=C3)C(C4=CC=C(Cl)C=C4Cl)=N2)=CC=C1[N+]([O-])=O.[H]Cl.[H]Cl
Formula: C20H19Cl4N9O2
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: CHIR98014 is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50s: 0.65 and 0.58 nM). Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50: 106 nM), potentiates insulin-dependent glucose transport in isolated muscle strips, and improves glucose disposal in diabetic animals.
Molecular Weight: 559, 23
