Product Overview
Pralsetinib HCl (2097132-94-8 free base) | TQ0277L | TargetMol Chemicals
CAS: TQ0277L
Smiles: O=C([C@@]1(OC)CC[C@@H](C2=NC(NC3=NNC(C)=C3)=CC(C)=N2)CC1)N[C@H](C4=CC=C(N5N=CC(F)=C5)N=C4)C.[H]Cl
Formula: C27H33ClFN9O2
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Pralsetinib is a selective and next-generation RET inhibitor (IC50: 0.3-0.4 nM for WT RET, RET mutants V804L, V804M, M918T, and CCDC6-RET fusion). BLU-667 is an effective and selective inhibitor of RET mutations, fusions, and predicted resistant mutants.
Molecular Weight: 570, 07
