Product Overview
α-Conotoxin MII | TP2063 | TargetMol Chemicals
CAS: 175735-93-0
Smiles: Gly-Cys-Cys-Ser-Asn-Pro-Val-Cys-His-Leu-Glu-His-Ser-Asn-Leu-Cys-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys16)
Formula: C67H103N23O22S4
Pathway: Neuroscience
Target: AChR
Receptor: N/A
Bioactivity: α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuronal nicotinic receptors. Displays > 200-fold selectivity for α3β2 over α2β2, α4β2 and α3β4.
Molecular Weight: 1710, 99
