Product Overview
CPI-455 HCl | T22299 | TargetMol Chemicals
CAS: 2095432-28-1
Smiles: Cl.CC(C)c1c([nH]c2c(cnn2c1=O)C#N)-c1ccccc1
Formula: C16H15ClN4O
Pathway: Chromatin/Epigenetic
Target: Histone Demethylase
Receptor: N/A
Bioactivity: CPI-455 is a specific KDM5 inhibitor with IC50 value of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with targeted agents or standard chemotherapy.
Molecular Weight: 314, 77
