Product Overview
CU-T12-9 | T15017 | TargetMol Chemicals
CAS: 1821387-73-8
Smiles: CNc1ccc(cc1-n1cnc(c1)-c1ccc(cc1)C(F)(F)F)[N+]([O-])=O
Formula: C17H13F3N4O2
Pathway: Immunology/Inflammation
Target: TLR
Receptor: N/A
Bioactivity: CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS.
Molecular Weight: 362, 312
