Product Overview
Cucurbitacin B | T3404 | TargetMol Chemicals
CAS: 6199-67-3
Smiles: CC(=O)OC(C)(C)\C=C\C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C[C@H](O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C
Formula: C32H46O8
Pathway: Angiogenesis|||Apoptosis|||Autophagy|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||JAK/STAT signaling|||Metabolism|||PI3K/Akt/mTOR signaling|||Stem Cells
Target: Apoptosis|||PTEN|||Integrin|||Endogenous Metabolite|||HIF|||STAT|||Autophagy
Receptor: N/A
Bioactivity: Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.
Molecular Weight: 558, 712
