Product Overview
Dacomitinib | T2483 | TargetMol Chemicals
CAS: 1110813-31-4
Smiles: COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CCCCC1
Formula: C24H25ClFN5O2
Pathway: Angiogenesis|||Apoptosis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors
Target: Apoptosis|||EGFR
Receptor: N/A
Bioactivity: Dacomitinib(PF299804; PF-00299804) is a highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.
Molecular Weight: 469, 95
