Product Overview
Dalpiciclib | T9636 | TargetMol Chemicals
CAS: 1637781-04-4
Smiles: CC(C1=C(C)c2cnc(Nc3ncc(C4CCNCC4)cc3)nc2N(C2CCCC2)C1=O)=O
Formula: C25H30N6O2
Pathway: Cell Cycle/Checkpoint
Target: CDK
Receptor: N/A
Bioactivity: Dalpiciclib is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4 nM and 9.9 nM, respectively. Dalpiciclib exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated tumor suppressor retinoblastoma protein (Rb) and inducing G1 cell cycle arrest.
Molecular Weight: 446, 54