Product Overview
Dasatinib monohydrate | T1448L | TargetMol Chemicals
CAS: 863127-77-9
Smiles: O.Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Formula: C22H28ClN7O3S
Pathway: Angiogenesis|||Apoptosis|||Autophagy|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors
Target: Apoptosis|||Bcr-Abl|||Src|||c-Kit|||Ephrin Receptor|||Autophagy
Receptor: N/A
Bioactivity: Dasatinib is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently, because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations.
Molecular Weight: 506, 02
