Product Overview
Dehydrocorydaline | T5S2358 | TargetMol Chemicals
CAS: 30045-16-0
Smiles: COc1ccc2c(C)c3-c4cc(OC)c(OC)cc4CC[n+]3cc2c1OC
Formula: C22H24NO4
Pathway: Apoptosis|||Autophagy|||Chromatin/Epigenetic|||DNA Damage/DNA Repair|||MAPK|||Microbiology/Virology|||Proteases/Proteasome
Target: BCL|||PARP|||p38 MAPK|||Caspase|||Parasite|||Autophagy
Receptor: N/A
Bioactivity: 1. Dehydrocorydaline exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSCLC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimerization of MyoD and E proteins, thus resulting in MyoD activation and myoblast differentiation. 3. Dehydrocorydaline shows antiplatelet effects, it inhibits thrombin-induced platelet aggregation in a low dose ( IC50= 34.914 ug/mL). 4. Dehydrocorydaline has anti-inflammatory and antinociceptive effects. 5. Dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP.
Molecular Weight: 366, 436
