Product Overview
Dovitinib | T6289 | TargetMol Chemicals
CAS: 405169-16-6
Smiles: CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O
Formula: C21H21FN6O
Pathway: Angiogenesis|||Tyrosine Kinase/Adaptors
Target: VEGFR|||FGFR|||FLT|||PDGFR|||c-Kit
Receptor: N/A
Bioactivity: Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit, IC50: 1/2 nM), also effective to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs (IC50: 8-13 nM), less potent to EGFR, InsR, EphA2, c-Met, IGF-1R, Tie2, and HER2.
Molecular Weight: 392, 438
