Product Overview
DS-8587 | T27211 | TargetMol Chemicals
CAS: 1356918-39-2
Smiles: O.O.Cl.Cc1c(N2C[C@]3(N)CCC[C@]3(F)C2)c(F)cc2c1n(cc(C(O)=O)c2=O)[C@@H]1C[C@@H]1F
Formula: C21H27ClF3N3O5
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: DS-8587 is a DNA topoisomerase inhibitor. DS-8587 exhibits potent antibacterial activity against quinolone-resistant A. baumannii isolates that harbor mutations in quinolone resistance-determining regions. DS-8587 significantly reduces the number of viable bacteria in a murine model of F. necrophorum-induced liver abscess. In the presence of the efflux pump inhibitor 1-(1-napthylmethyl)-piperazine, no significant changes were observed in the MIC for DS-8587.
Molecular Weight: 493, 91
